THE ANTIDIABETIC EFFECT OF KONJAC GLUCOMANNAN ON GLUCOSE LEVEL DIABETIC RATS

Sari, Alfia Pradita, Mashudi, Sugeng, Putra, Bryan Anggara, Afriani, Fany Risma and Putri, Dianita Rifqia (2023) THE ANTIDIABETIC EFFECT OF KONJAC GLUCOMANNAN ON GLUCOSE LEVEL DIABETIC RATS. Journal of Korean Academy of Psychiatric and Mental Health Nursing, 05 (04). 368 -385. ISSN ISSN:1225-8482 E-ISSN:2288-4653

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Abstract

Objectives: Type 2 Diabetes Mellitus (T2DM) describes a long-term endocrine disorder that disrupts different metabolic pathways defined by impaired insulin resistance as well as inadequate production of insulin, associated with abnormal sugar. Dietary prevention of T2DM has gained plenty of lately attention decades. As it turns out, the goal of this study is to explain the anti diabetic activities of Konjac glucomannan (KGM) in diabetic rats. Methods: This study's experimental design comprised of two groups of five male white rats each. The negative control group included of five diabetic rats. The positive control group was set out of diabetic rats created by glibenclamide at a dose of 0,7 ml intraperitoneal. Diabetic rats comprised the therapy group who were administered konjac glucomannan extract orally at a dose of 100 mg/kg b.w. as therapy. Prior to treatment, each subject's blood glucose level was measured using a glucometer by cutting the rat's tail and removing some of its blood. To confirm the results, glucose levels were checked again three and seven days after the participants had medication. Oneway analysis of variance (ANOVA) was used to analyze the data in SPSS. Results: The study's findings revealed that diabetic rats treated with konjac glucomannan extract had an effect similar to diabetic rats produced by glibenclamide, as indicated by a decrease in blood glucose levels, as evidenced by diabetes treatment therapy in general. Discussion: KGM reduced gluconeogenesis, liver marker enzymes, elevated genes, and insulin pathway protein expression which is distinguished by a drop in glucose levels. Conclusion: According to the most recent research, dietary KGM may be more beneficial for your health when treating T2DM.

Item Type:	Article
Uncontrolled Keywords:	Konjac glucomannan, Type 2 Diabetes Mellitus, Glucose Levels, Scizophrenia, Rats
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RT Nursing
Divisions:	Faculty of Health Sciences
Depositing User:	fik . userfik
Date Deposited:	02 Aug 2024 07:10
Last Modified:	02 Aug 2024 07:10
URI:	http://eprints.umpo.ac.id/id/eprint/14121

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