Potential of the methanol extract from Cucumis melo var. cantalupensis as an antihypertensive agent possibly through the interference of glutathione S-transferase

Purwaningroom, Dian Laila, Ishii, Toshinari, Setiowati, Tutut, Permatasari, Galuh Wening, Rosjidi, Cholik Harun and Munawaroh, Siti (2019) Potential of the methanol extract from Cucumis melo var. cantalupensis as an antihypertensive agent possibly through the interference of glutathione S-transferase. Drug Invention Today, 12 (12). pp. 2910-2818. ISSN 0975-7619

	Text 1 Artikel DIT.pdf Download (2MB)
	Text 2 Potential of the methanol extract from Cucumis melo var. cantalupensis as an antihypertensive agent possibly through the interference of glutathione S-transferase.pdf Download (2MB)
	Text 2 PR Potential.pdf Download (557kB)

Abstract

Background: Hypertension is a condition, in which a patient’s systolic blood pressure reaches ≥140 mmHg and/or the diastolic blood pressure reaches ≥90 mmHg. The disease is generally treated using synthetic chemical drugs such as angiotensin�converting enzyme (ACE) inhibitors. In Indonesia, especially the island of Java, people often use medicinal plants called Jamu (herbs) to treat hypertension. One of the most often used medicinal plants to treat hypertension is cantaloupe (Cucumis melo var. cantalupensis) or Blewah in Javanese. However, thus far, the mechanism of how cantaloupe reduces blood pressure is still unknown. Materials and Methods: This research aimed to investigate the working mechanism of cantaloupe in reducing blood pressure through an in silico approach. Results: An enzyme activity analysis showed that the methanol extract from cantaloupe inhibited the activity of ACE in a dose-dependent manner. Moreover, the mapping analysis of the interaction between the bioactive compounds and their target proteins, using the STITCH and STRINGdb databases, suggested that L-glutathione (GSH) (reduced) interacted with proteins that are members of the superfamily of GSH S-transferase (GST). Conclusion: This protein family acts in detoxification and radical scavenging. Thus, the possible working mechanism of cantaloupe in reducing blood pressure is through the detoxification and radical scavenging pathways by GST.

Item Type:	Article
Uncontrolled Keywords:	Antihypertension, Cucumis melo var. cantalupensis, Glutathione S-transferase
Subjects:	R Medicine > RT Nursing
Divisions:	Faculty of Health Sciences
Depositing User:	Library Umpo
Date Deposited:	07 Mar 2022 02:11
Last Modified:	15 Jul 2022 02:04
URI:	http://eprints.umpo.ac.id/id/eprint/3721

Actions (login required)

View Item