Prediksi Protein Target Bioaktif Ekstrak Metanol Buah Belimbing (Averrhoa carambola) dalam Regulasi Tekanan Darah

Munawaroh, Siti, Purwaningroom, Dian Laila, Putri, Dianita Rifqia and Rosjidi, Cholik Harun (2019) Prediksi Protein Target Bioaktif Ekstrak Metanol Buah Belimbing (Averrhoa carambola) dalam Regulasi Tekanan Darah. Jurnal Biotek Medisiana Indonesia, 8 (1). pp. 9-21. ISSN 2301-5810

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Abstract

Blood pressure regulation is basically control of amount of blood flow to certain tissues according to their metabolic needs. The complexity of the mechanisms involved leading to the assumption that there are many functional and structural proteins involved in blood pressure regulation. Indonesian people, especially those living on the island of Java, usually consume star fruit Averrhoa carambola to reduce blood pressure, but the content of bioactive compounds and the mechanism of their interference with proteins is still unknown. This study aimed to determine the bioactive compound content of Averrhoa carambola's methanol extract and its mechanism of interference with the target proteins. An amount of 200 g Averrhoa carambola dried simplicia was extracted by the maceration method using absolute methanol. The extract was then subjected to phytochemical tests using the Gas Chromatography-Mass Spectrometry (GC-MS) method. Based on the results obtained from the GC-MS phytochemical test, the names of the bioactive compounds found in the Averrhoa carambola methanol extract were obtained. The compounds are then analyzed for their target protein in the human body using the STITCH database (http://stitch.embl.de/). The proteins that had been predicted to be the target of active compounds of Averrhoa carambola methanol extract were analyzed for interactions between proteins using the STRINGdb database (https://string-db.org/cgi/input.pl). Based on this research, it can be concluded that Averrhoa carambola fruit methanol extract can help lower blood pressure by producing NO and acting as antioxidants. However, further research (in-vitro and in-vivo) needs to be done to prove the mechanism.

Item Type:	Article
Uncontrolled Keywords:	Keywords: protein target, Averrhoa carambola methanol extract, blood pressure regulation
Subjects:	R Medicine > RG Midwifery R Medicine > RT Nursing
Divisions:	Faculty of Health Sciences > Departement of Nursing D3 Faculty of Health Sciences > Departement of Nursing S1
Depositing User:	Library Umpo
Date Deposited:	18 Mar 2021 03:50
Last Modified:	15 Jul 2022 02:10
URI:	http://eprints.umpo.ac.id/id/eprint/6232

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