Different information and a lack of public understanding about the COVID-19 vaccination will cause a response of anxiety and concern that can hinder individual responses in making the right decisions. The purpose of this study was to determine whether or not there was a relationship between the level of knowledge about COVID-19 vaccination and public anxiety in Munggu Village, Bungkal District, Ponorogo Regency. This study uses a correlational research design using a cross sectional method. The population in this study was 3,849 people of Munggu Village, Bungkal District, Ponorogo Regency with a sample of 97 respondents. The sampling technique used is purposive sampling. Collecting data using a questionnaire and analyzed using the Fisher's Exact Test statistical test. The results of this study indicate that people in Munggu Village who have a good level of knowledge about Covid-19 vaccination are 88 people (90.7%), people who have mild anxiety are 61 (62.9%), from the analysis carried out the results have been obtained. that is, there is a relationship between the level of knowledge about covid-19 vaccination and public anxiety in Munggu Village, Bungkal District, Ponorogo Regency with p value (0.000) < (0.05) which means that there is a relationship between the level of knowledge about Covid-19 vaccination and public anxiety in Munggu Village, sub-district Bungkal, Ponorogo Regency. Knowledge has an important role in Covid-19 vaccination anxiety. It is hoped that Munggu Village will continue to carry out government programs, namely by carrying out Covid-19 vaccinations in order to prevent being exposed to Covid-19.