This study aimed to find the most dominant factors that affected student work-readiness in industry, namely career guidance, vocational learning in industry, work motivation, and entrepreneurial motivation. The research method used a non-experimental quantitative design using path analysis. The study used a sample of 205 vocational high school students majoring in Computer and Network Engineering. Data collection was carried out for 6 months. Data collection used questionnaires, tests, and observation instruments. This research result, in the finding of the most dominant factors, had a significant impact on work readiness. The findings were vocational learning in industry, career guidance, work motivation. On the other hand, entrepreneurial motivation did not have a significant impact on work readiness.