EXPLORING THE EFFICACY OF MUSA CAVENDISH STEM EXTRACT (MUCASE) AS A NOVEL WOUND DRESSING: A COMPARATIVE STUDY WITH SOFRATULLE®

Amanah, Nuraini Khoirotun, Mashudi, Sugeng, Munawaroh, Siti, Azzarin, Auliya Wanda, Karimah, Fadhilah Nurul and Gunawan, Fahmi (2024) EXPLORING THE EFFICACY OF MUSA CAVENDISH STEM EXTRACT (MUCASE) AS A NOVEL WOUND DRESSING: A COMPARATIVE STUDY WITH SOFRATULLE®. Cureus Journal of Medical Science, 16 (2). pp. 1-14. ISSN 2168-8184 (Electronic) 2168-8184 (Linking)

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Abstract

Background

This investigation explores the wound-healing potential of Musa Cavendish banana components. Specifically, the Musa Cavendish stem extract (MUCASE), comparatively assessing its efficacy against the commercial conventional wound dressing Sofratulle® as a sterile gauze containing the antibiotic framycetin sulfate BP 1%, designed for accelerating wound healing. While Musa Cavendish banana components have been acknowledged for their topical applications, scarce research has scrutinized the specific impact of MUCASE as a wound dressing, especially concerning its comparison with Sofratulle®.

Purpose

The primary objective is to evaluate and compare the effectiveness of Sofratulle® and varied concentrations of MUCASE in managing incision wounds.

Materials and methods

Fifteen male Rattus norvegicus rats were randomly allocated into five groups, each subjected to distinct treatments: 40%, 20%, 10% MUCASE, Sofratulle®, and negative control. Over a seven-day treatment span, measurements of the exudation along with the incision wounds' surface area and the rate of wound contraction were conducted.

Result

The findings revealed significant differences in wound conditions within each group pre- and post-dressing application, except for the negative control and MUCASE 10% groups. Particularly, MUCASE 10% exhibited suboptimal outcomes compared to MUCASE 40%, 20%, and Sofratulle®, showcasing a non-significant ratio of wound healing (p > 0.05). A comparable potential was exhibited by MUCASE 40%, 20%, and Sofratulle® in accelerating the healing of incisional wounds.

Conclusion

Both Sofratulle® and MUCASE are deemed suitable as wound dressings to facilitate efficient and swift wound healing. Nevertheless, the study's outcomes suggest that MUCASE surpasses Sofratulle® in accelerating the healing process of wounds.

Item Type:	Article
Uncontrolled Keywords:	rattus novergicus wistar, musa cavendish stem extract, sofratulle®, wound dressing, ­wound healing
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Health Sciences > Departement of Nursing S1
Depositing User:	fik . userfik
Date Deposited:	10 Jul 2024 02:19
Last Modified:	10 Jul 2024 02:19
URI:	https://eprints.umpo.ac.id/id/eprint/13976

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