Premature birth born at a gestational age of more than 20 weeks and 37 weeks. Several risk factors are associated with premature birth, including maternal age, parity, hypertension and premature rupture of membranes. The aim of this research is to determine the risk factors the incidence of premature births at RSU Darmayu Ponorogo. This research is a quantitative study using analytical methods with a cross sectional study design. The population used is all medical record data of mothers who gave birth to live newborn babies admitted to hospital at RSU Darmayu Ponorogo in June-December 2023, totaling 290 using Consecutive Sampling.
Based on statistical tests using Chi-Square, results were obtained with p-value < α (0.05), including maternal age (p-value = 0.005), premature rupture of membranes (p-value = 0.004), pre-eclampsia (p-value = 0.001), and anemia (p-value= 0.009). Meanwhile, p-value > α(0.05), namely parity (p-value = 0.719). The conclusion obtained from this study is that maternal age, premature rupture of membranes, pre-eclampsia, and anemia have a significant relationship with the incidence of premature births, whereas in this study there was no association between parity and the incidence of premature births. Meanwhile, the most dominant factor causing premature babies is anemia.