This study aims to determine the effect of Ease of Use, Product Diversity and Transaction Security on Buying Interest in Tokopedia E-Commerce. The method used in this study is a quantitative method. The data from this study were obtained from the results of distributing questionnaires with written statements to respondents and processed using SPSS 25 software. The population in this study was the community of Tokopedia e-commerce users in Ponorogo. The sample in this study amounted to 100 respondents using the purposive sampling technique. The results of this study indicate that: (1) There is an influence between Ease of Use on buying interest in Tokopedia e-commerce, (2) There is an influence between Product Diversity on buying interest in Tokopedia e-commerce, (3) There is an influence between Transaction Security on interest buy at Tokopedia e-commerce, (4) There is an influence between Ease of Use, Product Diversity and Transaction Security on buying interest in Tokopedia e-commerce.